Introduction to Italian Penicillin Soup
What is Italian Penicillin Soup?
Italian Penicillin Soup is a delightful and hearty dish that brings together the best of Italian comfort food. With tender chicken (often shredded rotisserie), colorful vegetables, and tiny pastina pasta swimming in a rich, savory broth, this soup is a go-to remedy for cold days or when you're feeling under the weather. The dish gets its unique flavor from a mix of herbs and a generous addition of Parmesan, giving it a depth that's both satisfying and nutritious.
Why is it called Penicillin Soup?
The term “Penicillin Soup” affectionately refers to this dish’s soothing and restorative qualities, akin to the comforting effects of chicken soup in general. There’s a cultural belief that a warm bowl of soup can help you feel better during times of sickness, just as penicillin works to heal. However, despite its whimsical name, this soup isn’t a medical cure. Instead, it serves as a delightful, flavor-packed meal that nourishes both the body and soul.
Curious to whip up your own version? Dive into our full recipe here to experience the warmth of this Italian classic!

Ingredients for Italian Penicillin Soup
Essential ingredients for a rich broth
Creating the perfect Italian Penicillin Soup starts with a robust foundation: the broth. A key ingredient is 8 cups of lower-sodium chicken broth, which provides a comforting base without overwhelming saltiness. The addition of thyme, bay leaves, and garlic elevates the flavor profile, making it both soothing and savory. If you’re looking for more tips on broth-making, consider checking out resources like The Kitchn.
Fresh vegetables for flavor
Fresh veggies play a pivotal role in this recipe. You’ll need 2 cups of chopped sweet onion, 1 ½ cups of coarsely chopped carrots, and 2 celery ribs for a balance of sweetness and earthiness. Each bite of these vegetables adds color and texture, turning your soup into a delightful feast for the senses. Feeling adventurous? Add some spinach or kale for an extra nutritional kick!
Importance of Parmigiano-Reggiano
Last but certainly not least, don’t skip the Parmigiano-Reggiano! You’ll want to add both a cheese rind during cooking and fresh, grated cheese for garnish. The rind imparts a unique umami flavor, while the freshly grated cheese adds richness and a touch of luxury. This Italian cheese is known for its complexity and depth, making it a must-have in Italian Penicillin Soup. For more insights about Parmesan cheese, visit American Cheese Society.
Preparing Italian Penicillin Soup
Gather and prep your ingredients
The first step in crafting your delicious Italian Penicillin Soup is gathering all your ingredients. Having everything ready to go can make the cooking process feel seamless and enjoyable. Here’s what you’ll need:
- 8 cups lower-sodium chicken broth
- 2 cups chopped sweet onion
- 1 ½ cups peeled and coarsely chopped carrots
- 2 celery ribs, coarsely chopped
- 6 garlic cloves, smashed and peeled
- ¾ teaspoon kosher salt
- 4 thyme sprigs
- 2 fresh bay leaves
- 1 (2 ounce) Parmigiano-Reggiano cheese rind, plus grated cheese for garnishing
- 4 ounces uncooked pastina pasta
- 2 cups shredded rotisserie chicken
- Fresh flat-leaf parsley for garnish
Taking a moment to chop your veggies and measure out your broth makes it easier to focus on the art of cooking.
Create a flavorful broth base
Once everything is prepped, it’s time to infuse that tantalizing flavor into the broth. Using a large saucepan or small Dutch oven, combine the chicken broth, onion, carrots, celery, garlic, and kosher salt. Bring it to a boil over high heat, then reduce the heat to medium-low. At this simmering stage, you'll want to cook until the vegetables are softened—this takes about 10 minutes.
This simmering process is essential because it allows the vegetables to release their natural flavors into the broth, creating a rich base for your Italian Penicillin Soup. If you're interested in enhancing broths at home, consider checking out resources from culinary experts like America's Test Kitchen.
Blend for a creamy texture
Now comes the exciting part: creating that creamy burst of flavor. Using a slotted spoon, transfer the softened vegetables and about 1 cup of the broth into a blender. Secure the lid and, here’s a handy tip, remove the center piece to let steam escape—this prevents any mess! Place a clean towel over the opening and blend until smooth, which should take roughly 30 seconds. Stir this velvety mixture back into your soup for that creamy, comforting texture we all crave.
Incorporate thyme, bay leaves, and pasta
Your soup is starting to look beautiful! Now it’s time to elevate the flavor with fresh herbs and pasta. Add the thyme sprigs, bay leaves, and the cheese rind to the mixture. Bring it back to a boil over medium-high heat, and then stir in the pastina pasta. Reduce the heat to medium-low again, simmering until the pasta is tender—this usually takes about 18 to 20 minutes.
Final touches with chicken and cheese
As your Italian Penicillin Soup simmers away, it’s a great time to incorporate the shredded rotisserie chicken into the mix during the last 3 minutes of cooking. The chicken adds protein and heartiness to your soup. After removing it from the heat, don’t forget to discard the thyme sprigs, bay leaves, and the beloved cheese rind!
Ready for serving? Garnish with fresh parsley and a generous sprinkle of grated Parmigiano-Reggiano cheese to elevate its taste. Enjoy your bowl of warmth and flavor!
If you need more inspiration for easy weeknight dinners, check out Food Network for further ideas!

Variations on Italian Penicillin Soup
Vegetarian Alternative
Want a hearty, plant-based twist on Italian Penicillin Soup? Substitute the chicken and chicken broth with vegetable broth and your favorite veggies! Think mushrooms for that umami kick and chickpeas for added protein. Leafy greens like spinach or kale can be tossed in just before serving to enhance the flavor and color. For a creamy texture, consider blending a portion of the soup with a splash of coconut milk or a sprinkle of nutritional yeast.
Spicy Kick with Additional Herbs
If you crave a little heat, add crushed red pepper flakes or sliced fresh chilies to your Italian Penicillin Soup. Fresh herbs can elevate the experience, too! Try incorporating basil or oregano for a fragrant twist. Cooking is all about experimenting — don’t shy away from your spice cabinet! Consider adding a dash of lemon juice or zest at the end for a refreshing lift. Your taste buds will thank you!
Feel free to share your variations with others — what unique touches have you made to your Italian Penicillin Soup?
Cooking tips and notes for Italian Penicillin Soup
Best practices for flavor enhancement
To elevate your Italian Penicillin Soup, consider sautéing the onions, carrots, and celery in olive oil before adding them to the broth. This extra step caramelizes the vegetables, adding a delightful depth to the flavor. Don't skip the cheese rind; it infuses the soup with umami richness. Experiment with additional herbs, like rosemary or oregano, for a personal twist. A dash of lemon juice just before serving brightens the flavors, making each spoonful sing.
How to properly store leftovers
After enjoying your comforting bowl of Italian Penicillin Soup, store leftovers in airtight containers in the refrigerator for up to three days. For longer storage, consider freezing the soup; simply cool completely and transfer to freezer-safe bags or containers. When ready to eat, thaw overnight in the fridge and reheat slowly on the stove for the best texture and flavor. For more tips on storing soups, check out resources like the Food Safety and Inspection Service.

Serving Suggestions for Italian Penicillin Soup
Pairing with Crusty Bread
One of the best ways to elevate your Italian Penicillin Soup experience is by serving it with slices of warm, crusty bread. This not only adds a delightful crunch but also allows you to soak up the rich broth in every spoonful—nothing beats dipping! Consider sourdough or ciabatta; their flavors complement the soup beautifully and add a rustic touch.
Garnishing for Presentation
To take your Italian Penicillin Soup from ordinary to extraordinary, don’t skip the garnishing step! Fresh flat-leaf parsley adds a pop of color and a fragrant finish, while a sprinkle of grated Parmigiano-Reggiano introduces a cheesy depth that’s hard to resist. Serve it in vibrant bowls to enhance the visual appeal, making every bite feel like a special occasion. For more serving ideas, check out articles on How to Plate Soups.
Time Breakdown for Italian Penicillin Soup
Preparation Time
Get ready to whip up this delightful Italian Penicillin Soup in just 10 minutes. Gather your ingredients, chop the veggies, and you’ll be set to start the cooking magic.
Cooking Time
The cooking process takes approximately 45 minutes, allowing the flavors of the chicken broth and fresh vegetables to meld beautifully. Don't rush—this is where the comforting aromas fill your kitchen!
Total Time
In under 55 minutes, you’ll have a cozy pot of Italian Penicillin Soup ready to nourish both your body and soul. Perfect for those busy evenings or a relaxing weekend meal with friends.
If you're looking for more Italian classics, consider checking out Food Network's Italian recipes for inspiration!
Nutritional Facts for Italian Penicillin Soup
Calories
This hearty bowl of Italian Penicillin Soup packs approximately 332 calories per serving, making it a satisfying choice for any meal without overdoing it.
Protein
You'll find a robust 28 grams of protein in each serving, thanks to the inclusion of shredded rotisserie chicken. It’s a great way to meet your protein needs, especially after a long day.
Sodium
Mindful of your sodium intake? This soup clocks in at around 1913 milligrams of sodium per serving. For a healthier option, consider using an even lower-sodium chicken broth, which can help keep your sodium levels in check while still delivering that comforting flavor.
Enjoy nourishing yourself with this delicious soup that not only warms the soul but also provides essential nutrients! For more on healthy choices, you can check out the USDA guidelines [here](https://www USDA.gov).
FAQs about Italian Penicillin Soup
Can I use different pasta types?
Absolutely! While the traditional recipe calls for pastina, you can easily swap it out for other small pasta shapes like orzo, ditalini, or even broken spaghetti. Just be mindful that different types may alter the cooking time slightly, so keep an eye on them as they simmer in the flavorful broth.
How long does the soup last in the fridge?
This delightful Italian Penicillin Soup will stay fresh in the fridge for about 3 to 4 days. Just make sure to store it in an airtight container to preserve its flavors! If you’re like many, you may find it even more comforting the next day, as the flavors have time to meld.
What can I substitute for chicken?
If you're looking for alternatives to chicken, consider using turkey, shredded pork, or even a hearty mix of beans for a vegetarian version. Each brings its own unique flavor profile, making your Italian Penicillin Soup versatile and suitable for various dietary preferences.
Feel free to explore these options, and don’t hesitate to reach out for more tips on making this cozy soup!
Conclusion on Italian Penicillin Soup
Italian Penicillin Soup is not just a meal; it's a comforting experience that blends rich flavors and nostalgia in every bowl. Perfect for chilly evenings or when you need a little boost, this recipe will quickly become your go-to for a deliciously soothing dish. Enjoy!

Italian Penicillin Soup
Equipment
- large saucepan
- blender
Ingredients
Broth and Vegetables
- 8 cups lower-sodium chicken broth
- 2 cups chopped sweet onion
- 1.5 cups peeled and coarsely chopped carrots
- 2 ribs celery coarsely chopped
- 6 cloves garlic smashed and peeled
- 0.75 teaspoon kosher salt
- 4 sprigs thyme
- 2 leaves fresh bay leaves
- 2 ounces Parmigiano-Reggiano cheese rind
Pasta and Chicken
- 4 ounces uncooked pastina pasta
- 2 cups shredded rotisserie chicken
Garnish
- fresh flat-leaf parsley leaves for garnish
- grated Parmigiano-Reggiano for garnish
Instructions
Preparation
- Gather all ingredients.
- Bring broth, onion, carrots, celery, garlic, and salt to a boil in a large saucepan or small Dutch oven over high. Reduce heat to medium-low, and simmer until vegetables are softened, about 10 minutes. Using a slotted spoon, transfer vegetables and 1 cup of broth to a blender.
- Secure lid on blender, and remove center piece to allow steam to escape. Place a clean towel over opening. Process until smooth, about 30 seconds. Stir blended carrot mixture back into soup.
- Add thyme sprigs, bay leaves, and Parmigiano-Reggiano cheese rind. Bring to a boil over medium-high. Add pasta, reduce heat to medium-low, and simmer, stirring occasionally, until pasta is tender, 18 to 20 minutes, adding shredded chicken in the last 3 minutes of cooking.
- Remove from heat. Remove and discard thyme sprigs, bay leaves, and Parmigiano-Reggiano cheese rind.
- Serve immediately; garnish with parsley and grated Parmigiano-Reggiano.





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